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天线 2

2022全球工程前沿 1

4比特可重构天线阵列 1

5G；交叉振子；双极化天线；终端天线；超宽带 1

60 GHz；天线阵列；线极化；圆极化；毫米波 1

60 GHz；封装天线；共面波导馈电环形谐振器；玻璃集成无源器件；超表面天线；小型化天线 1

Beclin-1 1

CDMA 1

FY-3湿度仪 1

MIMO阵列；5G手机；去耦方法 1

PID控制 1

PIN二极管 1

中小企业 1

中药 1

丹参酮IIA 1

二维插值 1

互耦；多输入多输出；天线阵列；超表面；去耦 1

人工智能 1

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用于无线供电物联网感知的电小尺寸惠更斯整流天线综述 Review

蔺炜, Richard W. Ziolkowski

《工程（英文）》 2022年第11卷第4期页码 42-59 doi: 10.1016/j.eng.2021.08.025

摘要：

远场无线电力传输（WPT）是一项重大突破性技术，它将支持许多预期中泛在的物联网（IoT）应用，而这些应用与第五代（5G）、第六代（6G）及以上无线生态系统相关。整流天线是整流电路和天线的组合，是远场WPT系统中最关键的组件。然而，紧凑型应用设备需要更小的集成整流天线，这些天线要同时具有大的电磁波捕获能力、高交流（AC）到直流（DC）转换效率，及促进多功能无线性能的作用。本文综述了各种整流天线的小型化技术，如曲折平面倒F天线（PIFA）整流天线、小型化的基于单极和偶极的整流天线、分形环和贴片整流天线、介质负载整流天线和电小尺寸近场谐振寄生整流天线。文中总结了它们的性能特征，并与我们之前开发的被证明更适合IoT 应用的电小尺寸惠更斯整流天线进行比较。例如，如本文所演示，它们经过定制可以成为无电池IoT 传感器。与电池供电设备相比，无电池的无线供电设备体积更小、重量更轻。此外，它们对环境友好，因此具有显著的社会效益。本文介绍了一系列高性能电小型惠更斯整流天线，包括惠更斯线极化（HLP）和圆极化（HCP）整流天线、基于这些设计的无线供电IoT 传感器以及双功能HLP整流天线和天线系统。最后，考虑两个线性均匀HLP整流天线阵列系统，以获得更为显著的大型无线电力捕获。示例阵列说明了如何有效将它们与DC或射频（RF）功率进行合成，从而促进IoT的实际应用。

关键词： Antenna Array Cardioid pattern Electrically small antenna Huygens dipole antenna Internet of Things (IoT) Rectenna Rectifier circuit Wireless power transfer

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Equivalent circuit and characteristic simulation of a brushless electrically excited synchronous wind

Hao WANG, Fengge ZHANG, Tao GUAN, Siyang YU

《机械工程前沿（英文）》 2017年第12卷第3期页码 420-426 doi: 10.1007/s11465-017-0439-9

摘要：

A brushless electrically excited synchronous generator (BEESG) with a hybrid rotor is a novel electrically excited synchronous generator. The BEESG proposed in this paper is composed of a conventional stator with two different sets of windings with different pole numbers, and a hybrid rotor with powerful coupling capacity. The pole number of the rotor is different from those of the stator windings. Thus, an analysis method different from that applied to conventional generators should be applied to the BEESG. In view of this problem, the equivalent circuit and electromagnetic torque expression of the BEESG are derived on the basis of electromagnetic relation of the proposed generator. The generator is simulated and tested experimentally using the established equivalent circuit model. The experimental and simulation data are then analyzed and compared. Results show the validity of the equivalent circuit model.

关键词： wind power brushless electrically excited synchronous generator hybrid rotor equivalent circuit

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Interference coordination in full-duplex HetNet with large-scale antenna arrays Article

Zhao-yang ZHANG, Wei LYU

《信息与电子工程前沿（英文）》 2017年第18卷第6期页码 830-840 doi: 10.1631/FITEE.1700047

摘要：对于未来的第五代通信系统，干扰协调已经成为最具挑战性的问题，而大规模多输入多输出、小蜂窝和全双工技术均是在此背景下充满前景的技术。提出一个针对两层异构网络的干扰协调框架，该异构网络包含了一个装备大规模天线阵列的宏蜂窝基站和大量使用全双工技术的小蜂窝基站。因为带内全双工和带外全双工会产生不同的干扰模式，为了抑制干扰和最大化网络吞吐量，每个小蜂窝基站在无线回程链路的全双工模式都应慎重选择。为解决此模式选择问题，提出两种集中式算法，分别是遗传算法和贪心算法。此外，为了更充分降低宏蜂窝基站的计算开销，进一步提出一种基于代价的分布式图染色算法。仿真结果表明：提出的算法显著提高了系统吞吐量。

关键词：大规模多输入多输出；全双工；小蜂窝；无线回程链路；分布式算法

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外加电场气相法制备纳米无机氧化物

庄清平

《中国工程科学》 2007年第9卷第2期页码 74-78

摘要：

气相燃烧法纳米无机氧化物粉体特征一方面取决于前驱体的水解反应速度和粒子的成核生长动力学，另一方面受到燃烧反应器内物料的流动混合、热质传递等多种过程因素的影响。电场控制气相燃烧法制备纳米无机氧化物是在原有的基础上外加电场，使火焰的轴向高度降低、径向宽度增大，形成厚度相对均匀的火焰层，火焰温度梯度也随之增大，抑制粒子表面的生长和粒子之间的烧结，获得“粒径分布较窄的粒子和结构相似的聚集体”。

关键词：气相燃烧法电场控制火焰纳米粒子聚集体

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基于LTCC技术与曲折线天线集成的封装天线系统

Gang DONG,Wei XIONG,Zhao-yao WU,Yin-tang YANG

《信息与电子工程前沿（英文）》 2016年第17卷第1期页码 67-73

摘要：

我们提出了一种基于低温共烧陶瓷（LTCC）技术的与弯折线天线集成的封装天线系统。该系统采用曲折线贴片天线，封装层和层压多芯片模块（MCM）来集成集成电路（IC）裸芯片。微带馈线用于减少贴片和封装之间的相互作用。为了减少电磁耦合，设计并分析了通孔结构。弯曲线天线的带宽为220 MHz，中心频率为2.4 GHz，最大增益为2.2 dB，辐射效率超过其工作频率的90％。整个系统具有20.2 mm×6.1 mm×2.6 mm的小尺寸，可通过标准LTCC工艺轻松实现。制作了集成了曲折线天线的封装天线系统，实验结果与仿真结果吻合良好。

关键词：封装天线（AiP），弯曲线天线，多芯片模块（MCM），低温共烧陶瓷（LTCC），

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

null

《医学前沿（英文）》 2015年第9卷第1期页码 108-111 doi: 10.1007/s11684-014-0344-0

摘要：

Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.

关键词： gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib

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Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

《能源前沿（英文）》 2016年第10卷第1期页码 37-45 doi: 10.1007/s11708-015-0390-6

摘要： Compared with the traditional engines, the thermo-acoustic engines are relatively new and can act as the linear compressors for refrigerators. Many institutes have shown great interest in this kind of machine for its absence of moving mechanical part. In this paper, the influence of the dimensions of the main parts of the small-scale Stirling thermo-acoustic engine was numerically simulated using a computer code called DeltaEC. The resonator and the resonator cavity were found to be the most convenient and effective in improving the performance of the engine. Based on the numerical simulation, a small-scale Stirling thermo-acoustic engine were constructed and experimentally investigated. Currently, with a resonator length of only 1 m, the working frequency of the engine was decreased to 90 Hz and the onset temperature difference was decreased to 198.2 K.

关键词： thermo-acoustic Stirling engine small-scale simulation experiment

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Discovery of small molecule degraders for modulating cell cycle

《医学前沿（英文）》页码 823-854 doi: 10.1007/s11684-023-1027-5

摘要： The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

关键词： PROTAC molecular glue degrader cell cycle CDK cyclin

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

《医学前沿（英文）》 2022年第16卷第3期页码 339-357 doi: 10.1007/s11684-022-0926-1

摘要： During mitosis, the allocation of genetic material concurs with organelle transformation and distribution. The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cell fate determination, and organismal homeostasis. Small GTPases belonging to the Ras superfamily regulate various cell organelles during division. Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases, such as cancer and Alzheimer’s disease. Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation. This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.

关键词： small GTPase cell organelle mitosis

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应用于5G/WLAN频段的MIMO手持天线 Correspondences

Yong CHENG, Jing LU, Bing-qing SHENG

《信息与电子工程前沿（英文）》 2020年第21卷第1期页码 182-187 doi: 10.1631/FITEE.1900478

摘要：提出一种用于便携式终端的多输入多输出（MIMO）天线。手持终端天线的工作频带为5G（3.4–3.8 GHz）和WLAN（5.150–5.925 GHz）。5G和WLAN频段的天线单元交错放置，尽量保证同频单元间距离较远，以减少天线元件间的耦合。所有天线元件回波损耗均大于6 dB。所有元件间隔离度大于14 dB。高频天线辐射效率大于50%，低频天线辐射效率大于40%。所有元件远场增益大于2.2 dBi。

关键词：第五代通信系统（5G）；手持天线；MIMO天线；去耦技术

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Gut microbiota and its implications in small bowel transplantation

null

《医学前沿（英文）》 2018年第12卷第3期页码 239-248 doi: 10.1007/s11684-018-0617-0

摘要：

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

关键词： gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy

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基于玻璃集成无源器件工艺的60-GHz小型化宽带超表面天线 Research Articles

Hai-yang XIA, Jin-can HU, Tao ZHANG, Lian-ming LI, Fu-chun ZHENG

《信息与电子工程前沿（英文）》 2020年第21卷第1期页码 174-181 doi: 10.1631/FITEE.1900453

摘要：提出一种面向封装天线应用的60-GHz小型化宽带超表面天线。基于玻璃集成无源器件制造技术，采用共面波导馈电环形谐振器表征玻璃基板的材料特性。该天线于高介电常数玻璃基板上设计以实现天线小型化。在TM10模式下，贴片单元之间的间隙使该天线贴片辐射孔径得以减小。该天线在结构上采用共面波导馈电，进而激励蝶形缝隙，最终耦合激励位于天线上表面的超表面贴片。该天线可同时支持TM10模和反相TM20模，从而提升带宽性能。经过设计、优化及加工，该天线的辐射贴片尺寸为0.31λ0×0.31λ0，厚度为0.06λ0。采用基于探针结构的天线测量装置完成该天线测试，测试结果显示天线带宽为53.3～67 GHz。在60 GHz频点处，该天线增益测量值约为5 dBi。

关键词： 60 GHz；封装天线；共面波导馈电环形谐振器；玻璃集成无源器件；超表面天线；小型化天线

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

《医学前沿（英文）》 2013年第7卷第2期页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要：

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词： non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling

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Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

《能源前沿（英文）》 2013年第7卷第1期页码 56-68 doi: 10.1007/s11708-012-0216-8

摘要： This paper presents the complete mathematical model and predicts the performance of switched reluctance generator with time average and small signal models. The complete mathematical model is developed in three stages. First, a switching model is developed based on quasi-linear inductance profile. Next, based on the switching behaviour, a time average model is obtained to measure the difference between the excitation and generation time in each switching cycle. Finally, to track control voltage and current wave shapes, a small signal model is designed. The effectiveness of the complete multilevel model combining electrical machine, power converter, load and control with programming language is demonstrated through simulations. A PI controller is used for controlling the voltage of the generator. The results presented show that the controller exhibits accurate tracking control of load voltage under different operating conditions. This demonstrates that the proposed model is able to perform an accurate control of the generated output voltage even in transient situations. The simulation is performed to choose the control parameters and study the performance of switched reluctance generator prior to its actual implementation. Initial experimental results are presented using NI-Data acquisition card to control the output power according to load requirements.

关键词： generator reluctance switching model small signal model time average model

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

《医学前沿（英文）》 2023年第17卷第1期页码 18-42 doi: 10.1007/s11684-022-0976-4

摘要： With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

关键词： non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint inhibitors